Characteristic of Nanostructured Lipid Carrier (NLC) diclofenac diethylammonium as function of ratio of glyceryl monostearate and caprylic acid

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چکیده

The present study investigated the characteristics of diclofenac diethylammonium-containing NLC as function ratio glyceryl monostearate (GMS) and caprylic acid (mygliol 80) 65:35; 75:25 85:15. There were three formulas composition each formula diethylammonium 1.16%; with (65:35; 85:15); Tween 80 5%; phosphate buffer pH 6.0 ± 0.1 dispersion medium. result showed that had different characteristic particle size efficiency entrapment. Particle was analized by DelsaTMNano, F I (65:35) 134.467 26.601 nm PI 11.776; II (75:25) 2252.233 727.370 0.348; III (85:15) 1500.867 219.673 0.260. Entrapment Efficiency (EE) carried out centrifuge method I, 88.342 0.52%, 73.764 0.511% 70.754 0.665%, respectively. analyzed statistic ANOVA one-way degree confident 95% (a = 0.005). Research revealed best in terms % GMS 65:35.

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ژورنال

عنوان ژورنال: Research Journal of Pharmacy and Technology

سال: 2021

ISSN: ['0974-360X']

DOI: https://doi.org/10.5958/0974-360x.2021.00302.4